Role of Cytochrome P450 In Drug Metabolism

The cytochrome P450 enzyme system is a large and diverse group of enzymes. CYP450 enzymes get their name from the fact that they are attached to cell membranes and have a heme pigment that, when exposed to carbon monoxide, absorbs light with a wavelength of 450 nm.

The majority of CYP enzymes are responsible for catalyzing the oxidation of organic compounds. Due to inhibition, induction, and competition for shared enzymatic pathways by many medications, it is the cause of a lot of drug interactions. This process can have substantial impact on the toxicity and efficacy of drugs.
Although CYP450 polymorphism genotyping has mostly been utilized for research, knowing how CYP enzymes function in drug metabolism is essential for creating safe and efficient medications.

CYP enzymes serve a variety of purposes, all of which emphasize how crucial they are to preserving homeostasis and shielding the body from dangerous compounds. It will be much easier to anticipate and avoid possible drug interactions and adverse effects if medical practitioners are aware of and understands the drug interactions involved in typical CYP pathways.

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